Effects of Mutated Pregnancy-Associated Plasma Protein-A on Atherosclerotic Lesion Development in Mice

Pregnancy-associated plasma protein-A (PAPP-A) is a large multidomain metalloprotease involved in cleavage of IGF binding protein (IGFBP)-4 and -5 thereby causing release of bioactive IGF. Individual domains of PAPP-A have been characterized in vitro, including the metzincin proteolytic domain impor...

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Main Authors: Boldt, Henning B., Bale, Laurie K., Resch, Zachary T., Oxvig, Claus, Overgaard, Michael T., Conover, Cheryl A.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2013
Assuntos:
Growth Factors-Cytokines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529381/
https://ncbi.nlm.nih.gov/pubmed/23161866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1552
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