Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development

Pregnancy-associated plasma protein-A (PAPP-A) increases local IGF-I bioavailability through cleavage of inhibitory IGF binding protein (IGFBP)-4 in a variety of systems, including the cardiovascular system. To test the hypothesis that expression of PAPP-A promotes the development of atherosclerotic...

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Detalhes bibliográficos
Main Authors: Conover, Cheryl A., Mason, Megan A., Bale, Laurie K., Harrington, Sean C., Nyegaard, Mette, Oxvig, Claus, Overgaard, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930380/
https://ncbi.nlm.nih.gov/pubmed/20472761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00904.2009
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