Inducible Knock Out of Pregnancy-Associated Plasma Protein-A Gene Expression in the Adult Mouse: Effect on Vascular Injury Response

Pregnancy-associated plasma protein-A (PAPP-A) enhances local IGF signaling through its ability to proteolyze inhibitory IGF binding proteins. In vivo, PAPP-A (like IGF) appears to exhibit antagonistic pleiotropy; ie, it has beneficial effects early in life but detrimental effects later in life. Acc...

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Bibliographische Detailangaben
Hauptverfasser: Conover, Cheryl A., Bale, Laurie K., Powell, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2013
Schlagworte:
Growth Factors-Cytokines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713220/
https://ncbi.nlm.nih.gov/pubmed/23748359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1320
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