mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation1,2. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. Through the use of integrative metabolomics in a mouse model3...

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Publicado no:Nature
Main Authors: Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martín-Martín, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Verónica, Cabrera, Diana, van Liempd, Sebastiaan M., Cendon, Ylenia, Castro, Elena, Murray, Stuart, Revandkar, Ajinkya, Alimonti, Andrea, Zhang, Yinan, Barnett, Amelia, Lein, Gina, Pirman, David, Cortazar, Ana R., Arreal, Leire, Prudkin, Ludmila, Astobiza, Ianire, Valcarcel-Jimenez, Lorea, Zuñiga-García, Patricia, Fernandez-Dominguez, Itziar, Piva, Marco, Caro-Maldonado, Alfredo, Sánchez-Mosquera, Pilar, Castillo-Martín, Mireia, Serra, Violeta, Beraza, Naiara, Gentilella, Antonio, Thomas, George, Azkargorta, Mikel, Elortza, Felix, Farràs, Rosa, Olmos, David, Efeyan, Alejo, Anguita, Juan, Muñoz, Javier, Falcón-Pérez, Juan M., Barrio, Rosa, Macarulla, Teresa, Mato, Jose M., Martinez-Chantar, Maria L., Cordon-Cardo, Carlos, Aransay, Ana M., Marks, Kevin, Baselga, José, Tabernero, Josep, Nuciforo, Paolo, Manning, Brendan D., Marjon, Katya, Carracedo, Arkaitz
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505479/
https://ncbi.nlm.nih.gov/pubmed/28658205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22964
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