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Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β

With the formidable growth in the volume of genetic information, it has become essential to identify and characterize mutations in macromolecules not only to predict contributions to disease processes but also to guide the design of therapeutic strategies. While mutations of certain residues have a...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Eckenroth, Brian E., Towle-Weicksel, Jamie B., Nemec, Antonia A., Murphy, Drew L., Sweasy, Joann B., Doublié, Sylvie
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501977/
https://ncbi.nlm.nih.gov/pubmed/28402631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01287
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