Transmembrane helical interactions in the CFTR channel pore

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF). Development of pharmaceutica...

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Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Das, Jhuma, Aleksandrov, Andrei A., Cui, Liying, He, Lihua, Riordan, John R., Dokholyan, Nikolay V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501672/
https://ncbi.nlm.nih.gov/pubmed/28640808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005594
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