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Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
The p53 tumor suppressor acts as a guardian of the genome in mammalian cells undergoing DNA double strand breaks induced by a various forms of cell stress, including inappropriate growth signals or ionizing radiation. Following damage, p53 protein levels become greatly elevated in cells and p53 func...
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| Veröffentlicht in: | Transl Cancer Res |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501481/ https://ncbi.nlm.nih.gov/pubmed/28690977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tcr.2016.11.75 |
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