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Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis
The p53 transcription factor regulates the expression of numerous genes whose products affect cell proliferation, senescence, cellular metabolism, apoptosis, and DNA repair. These p53-mediated effects can inhibit the growth of stressed or mutated cells and suppress tumorigenesis in the organism. How...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
SAGE Publications
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494369/ https://ncbi.nlm.nih.gov/pubmed/23150754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912455324 |
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