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Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

The p53 tumor suppressor acts as a guardian of the genome in mammalian cells undergoing DNA double strand breaks induced by a various forms of cell stress, including inappropriate growth signals or ionizing radiation. Following damage, p53 protein levels become greatly elevated in cells and p53 func...

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書目詳細資料
發表在:Transl Cancer Res
Main Authors: Carr, Michael I., Jones, Stephen N.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501481/
https://ncbi.nlm.nih.gov/pubmed/28690977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tcr.2016.11.75
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