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CRISPR–Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling
The RNA-guided CRISPR–Cas9 nuclease has revolutionized genome engineering, yet its mechanism for DNA target selection is not fully understood. A crucial step in Cas9 target recognition involves unwinding of the DNA duplex to form a three-stranded R-loop structure. Work reported here demonstrates dir...
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| Publicado en: | ACS Chem Biol |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501335/ https://ncbi.nlm.nih.gov/pubmed/28437608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01137 |
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