Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer

OBJECTIVE: Smad4 is a tumor suppressor that transduces transforming growth factor beta signaling and regulates genomic stability. We previously found that Smad4 knockdown in vitro inhibited DNA repair and increased sensitivity to DNA topoisomerase inhibitors. In this study, we assessed the associati...

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Bibliographic Details
Published in:Lung Cancer
Main Authors: Ziemke, Michael, Patil, Tejas, Nolan, Kyle, Tippimanchai, Darinee, Malkoski, Stephen P.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501281/
https://ncbi.nlm.nih.gov/pubmed/28577946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2017.04.017
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