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Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer
OBJECTIVE: Smad4 is a tumor suppressor that transduces transforming growth factor beta signaling and regulates genomic stability. We previously found that Smad4 knockdown in vitro inhibited DNA repair and increased sensitivity to DNA topoisomerase inhibitors. In this study, we assessed the associati...
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| Publicado no: | Lung Cancer |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501281/ https://ncbi.nlm.nih.gov/pubmed/28577946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2017.04.017 |
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