DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair

BACKGROUND: DNA double-strand breaks (DSBs) are the most cytotoxic form of DNA damage and are induced by ionizing radiation and specific chemotherapeutic agents, such as topoisomerase inhibitors. Cancer cells acquire resistance to such therapies by repairing DNA DSBs. A major pathway for the repair...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Yonago Acta Med
Κύριοι συγγραφείς: Yanai, Masaaki, Makino, Haruhiko, Ping, Bingqiong, Takeda, Kenichi, Tanaka, Natsumi, Sakamoto, Tomohiro, Yamaguchi, Kosuke, Kodani, Masahiro, Yamasaki, Akira, Igishi, Tadashi, Shimizu, Eiji
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Tottori University Faculty of Medicine 2017
Θέματα:
Original Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355839/
https://ncbi.nlm.nih.gov/pubmed/28331416
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