Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair

The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in non-homologous end-joining (NHEJ) repair. We investigated the mechanism of NU7441, a highly selective DNA-PK inhibitor, in NHEJ-competent mouse embryonic fibroblast (MEF) cells and NHEJ-deficient cells and explored the feasibi...

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發表在:Oncol Rep
Main Authors: Dong, Jun, Ren, Yufeng, Zhang, Tian, Wang, Zhenyu, Ling, Clifton C., Li, Gloria C., He, Fuqiu, Wang, Chengtao, Wen, Bixiu
格式: Artigo
語言:Inglês
出版: D.A. Spandidos 2018
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802037/
https://ncbi.nlm.nih.gov/pubmed/29344644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2018.6217
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