DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair

BACKGROUND: DNA double-strand breaks (DSBs) are the most cytotoxic form of DNA damage and are induced by ionizing radiation and specific chemotherapeutic agents, such as topoisomerase inhibitors. Cancer cells acquire resistance to such therapies by repairing DNA DSBs. A major pathway for the repair...

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Bibliographic Details
Published in:Yonago Acta Med
Main Authors: Yanai, Masaaki, Makino, Haruhiko, Ping, Bingqiong, Takeda, Kenichi, Tanaka, Natsumi, Sakamoto, Tomohiro, Yamaguchi, Kosuke, Kodani, Masahiro, Yamasaki, Akira, Igishi, Tadashi, Shimizu, Eiji
Format: Artigo
Language:Inglês
Published: Tottori University Faculty of Medicine 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355839/
https://ncbi.nlm.nih.gov/pubmed/28331416
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