The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats

The dopamine transporter (DAT) regulates dopamine (DA) neurotransmission by recapturing DA into the presynaptic terminals and is a principal target of the psychostimulant cocaine. The sigma-1 receptor (σ(1)R) is a molecular chaperone, and its ligands have been shown to modulate DA neuronal signaling...

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Vydáno v:J Biol Chem
Hlavní autoři: Hong, Weimin Conrad, Yano, Hideaki, Hiranita, Takato, Chin, Frederick T., McCurdy, Christopher R., Su, Tsung-Ping, Amara, Susan G., Katz, Jonathan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500793/
https://ncbi.nlm.nih.gov/pubmed/28495886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.774075
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