Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists

Sigma(1) receptors (σ(1)Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ(1)R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, ove...

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Main Authors: Hiranita, Takato, Mereu, Maddalena, Soto, Paul L, Tanda, Gianluigi, Katz, Jonathan L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572457/
https://ncbi.nlm.nih.gov/pubmed/23187725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.224
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