CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

CDK12 (cyclin-dependent kinase 12) is a regulatory kinase with evolutionarily conserved roles in modulating transcription elongation. Recent tumor genome studies of breast and ovarian cancers highlighted recurrent CDK12 mutations, which have been shown to disrupt DNA repair in cell-based assays. In...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Tien, Jerry F., Mazloomian, Alborz, Cheng, S.-W. Grace, Hughes, Christopher S., Chow, Christalle C.T., Canapi, Leanna T., Oloumi, Arusha, Trigo-Gonzalez, Genny, Bashashati, Ali, Xu, James, Chang, Vicky C.-D., Shah, Sohrab P., Aparicio, Samuel, Morin, Gregg B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
RNA
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499812/
https://ncbi.nlm.nih.gov/pubmed/28334900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx187
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