Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation

The RNA helicase EIF4A3 regulates the exon junction complex and nonsense-mediated mRNA decay functions in RNA transcript processing. However, a transcriptome-wide network definition of these functions has been lacking, in part due to the lack of suitable pharmacological inhibitors. Here we employ sh...

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Vydáno v:Commun Biol
Hlavní autoři: Mazloomian, Alborz, Araki, Shinsuke, Ohori, Momoko, El-Naggar, Amal M., Yap, Damian, Bashashati, Ali, Nakao, Shoichi, Sorensen, Poul H., Nakanishi, Atsushi, Shah, Sohrab, Aparicio, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499833/
https://ncbi.nlm.nih.gov/pubmed/31069274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0391-9
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