Oncogenic activation of c-ABL by mutation within its last exon.

The c-ABL proto-oncogene is a predominantly nuclear localized tyrosine kinase. A random mutagenesis scheme was used to isolate c-ABL mutants whose expression produced a transformed phenotype in rodent fibroblast cells. An in-frame deletion within the central region of the last exon was identified in...

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Detalhes bibliográficos
Main Authors: Goga, A, McLaughlin, J, Pendergast, A M, Parmar, K, Muller, A, Rosenberg, N, Witte, O N
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC360140/
https://ncbi.nlm.nih.gov/pubmed/8336729
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