Oncogenic activation of c-ABL by mutation within its last exon.

The c-ABL proto-oncogene is a predominantly nuclear localized tyrosine kinase. A random mutagenesis scheme was used to isolate c-ABL mutants whose expression produced a transformed phenotype in rodent fibroblast cells. An in-frame deletion within the central region of the last exon was identified in...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Goga, A, McLaughlin, J, Pendergast, A M, Parmar, K, Muller, A, Rosenberg, N, Witte, O N
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8336729/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4967-4975.1993
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