In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

The Philadelphia chromosome [t(9;22)-(q34;q11)] is the cytogenetic hallmark of human chronic myelogenous leukemia. RNA splicing joins sequences from a gene on chromosome 22 (BCR) across the translocation breakpoint to a portion of the ABL oncogene from chromosome 9, resulting in a chimeric protein (...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	McLaughlin, J, Chianese, E, Witte, O N
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3498165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.18.6558
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