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Oncogenic activation of c-ABL by mutation within its last exon.

The c-ABL proto-oncogene is a predominantly nuclear localized tyrosine kinase. A random mutagenesis scheme was used to isolate c-ABL mutants whose expression produced a transformed phenotype in rodent fibroblast cells. An in-frame deletion within the central region of the last exon was identified in...

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Udgivet i:Mol Cell Biol
Principais autores: Goga, A, McLaughlin, J, Pendergast, A M, Parmar, K, Muller, A, Rosenberg, N, Witte, O N
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360140/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8336729/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4967-4975.1993
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