Lanean...

PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination

Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic cell death is triggered. Inhibiting the ubiquitination of p53 under con...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biomol Ther (Seoul)
Egile Nagusiak: Jin, Min, Park, Seon-Joo, Kim, Seok Won, Kim, Hye Rim, Hyun, Jin Won, Lee, Jung-Hee
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Korean Society of Applied Pharmacology 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499618/
https://ncbi.nlm.nih.gov/pubmed/28605833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2017.086
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!