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PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination
Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic cell death is triggered. Inhibiting the ubiquitination of p53 under con...
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| Vydáno v: | Biomol Ther (Seoul) |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Korean Society of Applied Pharmacology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499618/ https://ncbi.nlm.nih.gov/pubmed/28605833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2017.086 |
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