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Critical Contribution of the MDM2 Acidic Domain to p53 Ubiquitination
MDM2 is an E3 ubiquitin ligase that targets p53 for proteasomal degradation. Recent studies have shown, however, that the ring-finger domain (RFD) of MDM2, where the ubiquitin E3 ligase activity resides, is necessary but not sufficient for p53 ubiquitination, suggesting that an additional activity o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC162226/ https://ncbi.nlm.nih.gov/pubmed/12832479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4939-4947.2003 |
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