Critical Contribution of the MDM2 Acidic Domain to p53 Ubiquitination

MDM2 is an E3 ubiquitin ligase that targets p53 for proteasomal degradation. Recent studies have shown, however, that the ring-finger domain (RFD) of MDM2, where the ubiquitin E3 ligase activity resides, is necessary but not sufficient for p53 ubiquitination, suggesting that an additional activity o...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Kawai, Hidehiko, Wiederschain, Dmitri, Yuan, Zhi-Min
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	Cell Growth and Development
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4939-4947.2003
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!