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Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination
Previously, we defined SCYL1-BP1 to be a substrate of Pirh2 that binds to MDM2. In the current study, we found that an increase in SCYL1-BP1 protein levels caused a parallel change in the amount of p53 protein due to the inhibition by SCYL-BP1 of MDM2-mediated p53 ubiquitination. SCYL1-BP1 was not a...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3789512/ https://ncbi.nlm.nih.gov/pubmed/20849854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.09.019 |
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