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A Newly Identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination
The SCYL1-BP1 protein was identified as an interacting partner of E3 ligase Pirh2 and MDM2 by yeast two-hybrid screening. Further investigation suggested there are two interactions involved in different mechanisms. SCYL1-BP1 can be ubiquitinated and degraded by Pirh2 but not by MDM2, which suggests...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798065/ https://ncbi.nlm.nih.gov/pubmed/20598683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.06.027 |
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