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Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity
The RING domain E3 ubiquitin ligase Mdm2 is the master regulator of the tumor suppressor p53. It targets p53 for proteasomal degradation, restraining the potent activity of p53 and enabling cell survival and proliferation. Like most E3 ligases, Mdm2 can also ubiquitinate itself. How Mdm2 auto-ubiqui...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696669/ https://ncbi.nlm.nih.gov/pubmed/23671280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.454470 |
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