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Mdm2 enhances ligase activity of parkin and facilitates mitophagy
Loss-of-function mutations in the E3 ubiquitin ligase parkin have been implicated in the death of dopaminergic neurons in the substantia nigra, which is the root cause of dopamine deficit in the striatum in Parkinson's disease. Parkin ubiquitinates proteins on mitochondria that lost membrane po...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7081349/ https://ncbi.nlm.nih.gov/pubmed/32193420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61796-4 |
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