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Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination

Numerous mutations in E3 ubiquitin ligase parkin were shown to associate with familial Parkinson's disease. Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmuno-precipitation of endogenous proteins from brain...

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Hlavní autoři: Ahmed, M. Rafiuddin, Zhan, Xuanzhi, Song, Xiufeng, Kook, Seunghyi, Gurevich, Vsevolod V., Gurevich, Eugenia V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091828/
https://ncbi.nlm.nih.gov/pubmed/21466165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200175q
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