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Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination
Numerous mutations in E3 ubiquitin ligase parkin were shown to associate with familial Parkinson's disease. Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmuno-precipitation of endogenous proteins from brain...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091828/ https://ncbi.nlm.nih.gov/pubmed/21466165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200175q |
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