Replication studies of carboxymethylated DNA lesions in human cells

Metabolic activation of some N-nitroso compounds (NOCs), an important class of DNA damaging agents, can induce the carboxymethylation of nucleobases in DNA. Very little was previously known about how the carboxymethylated DNA lesions perturb DNA replication in human cells. Here, we investigated the...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wu, Jun, Wang, Pengcheng, Li, Lin, Williams, Nicole L., Ji, Debin, Zahurancik, Walter J., You, Changjun, Wang, Jianshuang, Suo, Zucai, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499590/
https://ncbi.nlm.nih.gov/pubmed/28531304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx442
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