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DNA substrate recognition and processing by the full-length human UPF1 helicase
UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm. Human UPF1 (hUPF1) is also needed for nuclear DNA replication. While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response and cell cycle arrest. We have analysed nucle...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499549/ https://ncbi.nlm.nih.gov/pubmed/28541562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx478 |
| Oznake: |
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