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DNA substrate recognition and processing by the full-length human UPF1 helicase

UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm. Human UPF1 (hUPF1) is also needed for nuclear DNA replication. While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response and cell cycle arrest. We have analysed nucle...

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Pubblicato in:Nucleic Acids Res
Autori principali: Dehghani-Tafti, Saba, Sanders, Cyril M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499549/
https://ncbi.nlm.nih.gov/pubmed/28541562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx478
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