Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks

Pif-1 proteins are 5′→3′ superfamily 1 (SF1) helicases that in yeast have roles in the maintenance of mitochondrial and nuclear genome stability. The functions and activities of the human enzyme (hPif1) are unclear, but here we describe its DNA binding and DNA remodeling activities. We demonstrate t...

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Bibliographic Details
Main Authors: George, Tresa, Wen, Qin, Griffiths, Richard, Ganesh, Anil, Meuth, Mark, Sanders, Cyril M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770657/
https://ncbi.nlm.nih.gov/pubmed/19700773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp671
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