Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory information originating in the periphery. However, the effects of the acute and selective inactivation of GABAergic SDH interneurons on pain processing are not fully understood. In this study, we used de...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koga, Keisuke, Kanehisa, Kensho, Kohro, Yuta, Shiratori-Hayashi, Miho, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide, Furue, Hidemasa, Tsuda, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498492/
https://ncbi.nlm.nih.gov/pubmed/28680103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04972-3
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