Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory information originating in the periphery. However, the effects of the acute and selective inactivation of GABAergic SDH interneurons on pain processing are not fully understood. In this study, we used de...

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Pubblicato in:Sci Rep
Autori principali: Koga, Keisuke, Kanehisa, Kensho, Kohro, Yuta, Shiratori-Hayashi, Miho, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide, Furue, Hidemasa, Tsuda, Makoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498492/
https://ncbi.nlm.nih.gov/pubmed/28680103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04972-3
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