Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is there...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Mwenechanya, Roy, Kovářová, Julie, Dickens, Nicholas J., Mudaliar, Manikhandan, Herzyk, Pawel, Vincent, Isabel M., Weidt, Stefan K., Burgess, Karl E., Burchmore, Richard J. S., Pountain, Andrew W., Smith, Terry K., Creek, Darren J., Kim, Dong-Hyun, Lepesheva, Galina I., Barrett, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498063/
https://ncbi.nlm.nih.gov/pubmed/28622334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005649
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