Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana. Whereas the deletion had no obvious effect on cultured promastigote forms of the parasite, the Δtkt c...

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Udgivet i:PLoS Pathog
Main Authors: Kovářová, Julie, Pountain, Andrew W., Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J. S., Achcar, Fiona, Barrett, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882173/
https://ncbi.nlm.nih.gov/pubmed/29554142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006953
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