Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana. Whereas the deletion had no obvious effect on cultured promastigote forms of the parasite, the Δtkt c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Kovářová, Julie, Pountain, Andrew W., Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J. S., Achcar, Fiona, Barrett, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882173/
https://ncbi.nlm.nih.gov/pubmed/29554142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006953
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados