Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites

Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance to this drug is a considerable threat. Here we ch...

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Publicado en:PLoS Negl Trop Dis
Autores principales: Pountain, Andrew W., Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J., Barrett, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375703/
https://ncbi.nlm.nih.gov/pubmed/30716073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007052
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