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Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites

Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance to this drug is a considerable threat. Here we ch...

詳細記述

保存先:
書誌詳細
出版年:PLoS Negl Trop Dis
主要な著者: Pountain, Andrew W., Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J., Barrett, Michael P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375703/
https://ncbi.nlm.nih.gov/pubmed/30716073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007052
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