Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites

Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance to this drug is a considerable threat. Here we ch...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Pountain, Andrew W., Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J., Barrett, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375703/
https://ncbi.nlm.nih.gov/pubmed/30716073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007052
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