Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mutation in a conserved cysteine in CD59 prevented the...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Allan, Christopher M., Jung, Cris J., Larsson, Mikael, Heizer, Patrick J., Tu, Yiping, Sandoval, Norma P., Dang, Tiffany Ly P., Jung, Rachel S., Beigneux, Anne P., de Jong, Pieter J., Fong, Loren G., Young, Stephen G.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496041/
https://ncbi.nlm.nih.gov/pubmed/28476858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076943
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