Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mutation in a conserved cysteine in CD59 prevented the...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Allan, Christopher M., Jung, Cris J., Larsson, Mikael, Heizer, Patrick J., Tu, Yiping, Sandoval, Norma P., Dang, Tiffany Ly P., Jung, Rachel S., Beigneux, Anne P., de Jong, Pieter J., Fong, Loren G., Young, Stephen G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496041/
https://ncbi.nlm.nih.gov/pubmed/28476858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076943
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