Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mutation in a conserved cysteine in CD59 prevented the...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Lipid Res
Päätekijät: Allan, Christopher M., Jung, Cris J., Larsson, Mikael, Heizer, Patrick J., Tu, Yiping, Sandoval, Norma P., Dang, Tiffany Ly P., Jung, Rachel S., Beigneux, Anne P., de Jong, Pieter J., Fong, Loren G., Young, Stephen G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496041/
https://ncbi.nlm.nih.gov/pubmed/28476858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076943
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