Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL

GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclonal antibodies (mAbs) against human GPIHBP1 would...

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Détails bibliographiques
Publié dans:J Lipid Res
Auteurs principaux: Hu, Xuchen, Sleeman, Mark W., Miyashita, Kazuya, Linton, MacRae F., Allan, Christopher M., He, Cuiwen, Larsson, Mikael, Tu, Yiping, Sandoval, Norma P., Jung, Rachel S., Mapar, Alaleh, Machida, Tetsuo, Murakami, Masami, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G., Beigneux, Anne P.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234723/
https://ncbi.nlm.nih.gov/pubmed/27875259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M072462
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