Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL

GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclonal antibodies (mAbs) against human GPIHBP1 would...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Hu, Xuchen, Sleeman, Mark W., Miyashita, Kazuya, Linton, MacRae F., Allan, Christopher M., He, Cuiwen, Larsson, Mikael, Tu, Yiping, Sandoval, Norma P., Jung, Rachel S., Mapar, Alaleh, Machida, Tetsuo, Murakami, Masami, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G., Beigneux, Anne P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234723/
https://ncbi.nlm.nih.gov/pubmed/27875259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M072462
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