Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

We recently identified pathogenic KIF1Bβ mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis. Here we deleted KIF1Bβ in the mouse sympathetic nervous system and observed impaired sympathetic nervous function and misexpression of genes required for sympa...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Fell, Stuart M., Li, Shuijie, Wallis, Karin, Kock, Anna, Surova, Olga, Rraklli, Vilma, Höfig, Carolin S., Li, Wenyu, Mittag, Jens, Henriksson, Marie Arsenian, Kenchappa, Rajappa S., Holmberg, Johan, Kogner, Per, Schlisio, Susanne
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495120/
https://ncbi.nlm.nih.gov/pubmed/28637693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297077.117
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