Gene Editing with Helper-Dependent Adenovirus Can Efficiently Introduce Multiple Changes Simultaneously over a Large Genomic Region

Helper-dependent adenoviral vectors (HDAds) possess long homology arms that mediate high-efficiency gene editing. These long homology arms may permit simultaneous introduction of multiple modifications into a large genomic region or may permit a single HDAd to correct many different individual mutat...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Palmer, Donna J., Grove, Nathan C., Turner, Dustin L., Ng, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493818/
https://ncbi.nlm.nih.gov/pubmed/28918012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.06.001
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