Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors

Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off-target cleavage. Because of their large cloning capacity of 37 kb, helper-dependent adenoviral vectors with long homology arms are used...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Palmer, Donna J, Grove, Nathan C, Ing, Jordan, Crane, Ana M, Venken, Koen, Davis, Brian R, Ng, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095686/
https://ncbi.nlm.nih.gov/pubmed/27727248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.83
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