Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors

Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off-target cleavage. Because of their large cloning capacity of 37 kb, helper-dependent adenoviral vectors with long homology arms are used...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Ther Nucleic Acids
मुख्य लेखकों: Palmer, Donna J, Grove, Nathan C, Ing, Jordan, Crane, Ana M, Venken, Koen, Davis, Brian R, Ng, Philip
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2016
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095686/
https://ncbi.nlm.nih.gov/pubmed/27727248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.83
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