Microhomology-assisted scarless genome editing in human iPSCs

Gene-edited induced pluripotent stem cells (iPSCs) provide relevant isogenic human disease models in patient-specific or healthy genetic backgrounds. Towards this end, gene targeting using antibiotic selection along with engineered point mutations remains a reliable method to enrich edited cells. Ne...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kim, Shin-Il, Matsumoto, Tomoko, Kagawa, Harunobu, Nakamura, Michiko, Hirohata, Ryoko, Ueno, Ayano, Ohishi, Maki, Sakuma, Tetsushi, Soga, Tomoyoshi, Yamamoto, Takashi, Woltjen, Knut
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838097/
https://ncbi.nlm.nih.gov/pubmed/29507284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03044-y
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