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Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line
Ikaros is a hematopoietic cell-specific zinc finger DNA binding protein that plays an important role in lymphocyte development. Genetic disruption of Ikaros results in T-cell transformation. Ikaros null mice develop leukemia with 100% penetrance. It has been hypothesized that Ikaros controls gene ex...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549358/ https://ncbi.nlm.nih.gov/pubmed/15713624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.1645-1654.2005 |
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