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Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line: IMPLICATIONS FOR CD4 REGULATION

Ikaros and Notch1, two regulators of gene transcription, are critically important at many stages of T cell development. Deregulation of Ikaros and Notch activities cooperate to promote T cell leukemogenesis, providing evidence that they function in converging pathways in developing T cells. In this...

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Bibliographische Detailangaben
Hauptverfasser: Kathrein, Katie L., Chari, Sheila, Winandy, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447659/
https://ncbi.nlm.nih.gov/pubmed/18287091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709643200
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