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Notch Target Gene Deregulation and Maintenance of the Leukemogenic Phenotype Do Not Require RBP-Jκ in Ikaros Null Mice
Ikaros and Notch are transcriptional regulators essential for normal T cell development. Aberrant activation of Notch target genes is observed in Ikaros-deficient thymocytes as well as leukemia cell lines. However, it is not known whether Notch deregulation plays a preferential or obligatory role in...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955868/ https://ncbi.nlm.nih.gov/pubmed/20511547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903688 |
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